COMPANY PROFILE

Endacea, Inc. (RTP, NC), an emerging biopharmaceutical company, is developing a series of proprietary A₁ adenosine receptor (AR) antagonists as drug candidates for a number of medical indications: 1) inflammation, including sepsis and asthma; and 2) renal impairment. Endacea is advancing the Company's lead compound A₁ AR antagonist, L-97-1, as an i.v. anti-sepsis drug candidate and as a post-exposure medical countermeasure for plague and other biodefense indications. Endacea is also developing an endotoxin assay as a sensitive and specific biomarker to detect patients with or at risk of sepsis and for other uses. Endacea recently formed a subsidiary, Endacea Diagnostics, Inc. to develop this assay.

Endacea’s lead compound A₁ AR antagonist, L-97-1, is a water-soluble, orally bioavailable “best in class” A₁ AR antagonist late preclinical drug candidate. Endacea’s patent estate includes issued and pending U.S. patents for compositions of matter for L-97-1 and follow-on A₁ AR antagonists, as well as methods of use patents, e.g. sepsis, and a pending application for a new endotoxin assay.

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